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Jean-Sébastien Hoffmann Selected Research

DNA Polymerase beta (DNA Polymerase IV)

1/2006Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia.
1/2004DNA polymerase beta overexpression stimulates the Rad51-dependent homologous recombination in mammalian cells.
12/2002A role for DNA polymerase beta in mutagenic UV lesion bypass.
6/2002Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.
4/2002Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities.

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Jean-Sébastien Hoffmann Research Topics

Disease

23Neoplasms (Cancer)
11/2021 - 04/2002
9Genomic Instability
06/2021 - 06/2002
6Carcinogenesis
01/2022 - 06/2002
5Breast Neoplasms (Breast Cancer)
08/2021 - 07/2010
4Chromosomal Instability (Chromosome Stability)
10/2009 - 04/2002
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2020 - 01/2016
3Aneuploidy (Aneuploid)
01/2005 - 06/2002
2Lung Neoplasms (Lung Cancer)
06/2021 - 01/2005
2Hematologic Neoplasms (Hematological Malignancy)
09/2019 - 01/2018
2Chromosome Aberrations (Chromosome Abnormalities)
10/2009 - 04/2002
1Colorectal Neoplasms (Colorectal Cancer)
01/2022
1Bites and Stings (Sting)
06/2021
1Esophageal Squamous Cell Carcinoma
06/2021
1Triple Negative Breast Neoplasms
01/2021
1Adenocarcinoma
11/2019
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2018
1Ataxia Telangiectasia (Louis Bar Syndrome)
01/2014
1Parasitic Diseases (Parasitic Disease)
06/2012
1Skin Neoplasms (Skin Cancer)
06/2009
1Chromosome Breakage
06/2009
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2006
1Complementation Group B Xeroderma Pigmentosum
10/2003
1Melanoma (Melanoma, Malignant)
12/2002

Drug/Important Bio-Agent (IBA)

10DNA (Deoxyribonucleic Acid)IBA
08/2021 - 04/2002
10DNA-Directed DNA Polymerase (Polymerases, DNA)IBA
04/2021 - 05/2004
5EnzymesIBA
10/2010 - 04/2002
5DNA Polymerase beta (DNA Polymerase IV)IBA
01/2006 - 04/2002
3Proteins (Proteins, Gene)FDA Link
01/2022 - 06/2002
3Transcription Factors (Transcription Factor)IBA
01/2022 - 01/2021
31,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
08/2021 - 10/2009
3DNA Polymerase thetaIBA
06/2021 - 07/2010
3NucleotidesIBA
06/2012 - 04/2002
2Telomerase (Telomerase Reverse Transcriptase)IBA
02/2021 - 11/2016
2ClaudinsIBA
01/2021 - 01/2021
2A-Form DNA (A-DNA)IBA
09/2019 - 11/2014
2Checkpoint Kinase 1IBA
01/2019 - 07/2013
2Biomarkers (Surrogate Marker)IBA
01/2018 - 11/2014
2Proliferating Cell Nuclear Antigen (PCNA)IBA
10/2016 - 10/2003
1LuciferasesIBA
01/2022
1Nuclear Receptor Interacting Protein 1IBA
09/2021
1Poly(ADP-ribose) Polymerase InhibitorsIBA
08/2021
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
08/2021
1RNA (Ribonucleic Acid)IBA
06/2021
1Zinc Finger E-box-Binding Homeobox 1IBA
01/2021
15- hydroxy- 6- (2- (1H- imidazol- 4- yl)ethylamino)cholestan- 3- olIBA
10/2020
1AnthracyclinesIBA
10/2020
1CholesterolIBA
10/2020
1bis(p-chlorophenyl)acetic acid (DDA)IBA
10/2020
1RNA Helicases (RNA Helicase)IBA
11/2019
1silvestrolIBA
11/2019
1fludarabineIBA
01/2018
1ProteomeIBA
11/2016
1Pharmaceutical PreparationsIBA
11/2016
1Cytarabine (Cytosar-U)FDA LinkGeneric
01/2016
1NucleosidesIBA
01/2016
1triplex DNA (H-DNA)IBA
11/2013
1Z-Form DNA (Z-DNA)IBA
11/2013
1Single-Stranded DNA (DNA, Single Stranded)IBA
07/2013
1Reactive Oxygen Species (Oxygen Radicals)IBA
06/2012
17,8-dihydro-8-oxoguanineIBA
06/2012
12- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
10/2010
1Cyclin EIBA
07/2010
1Indicators and Reagents (Reagents)IBA
07/2010
1DNA polymerase beta2IBA
10/2009
1Oncogene Proteins (Oncogene Protein)IBA
06/2009
1Small Interfering RNA (siRNA)IBA
06/2009
1Pyrimidine DimersIBA
06/2009
1Rad30 proteinIBA
06/2009
1DNA Repair EnzymesIBA
01/2004
1TubulinIBA
06/2002
1Biological ProductsIBA
06/2002
18-oxodeoxyguanosine triphosphateIBA
04/2002
1purineIBA
04/2002
1deoxyguanosine triphosphate (dGTP)IBA
04/2002

Therapy/Procedure

3Therapeutics
11/2021 - 01/2017
1Drug Therapy (Chemotherapy)
09/2019